Post-doctoral Fellow - Osteoarthritis

Job Locations US-OK-Oklahoma City
 Arthritis & Clinical Immunology - Jeffries


OMRF is an independent, not-for-profit biomedical research institute adjacent to the University of Oklahoma Health Sciences Center (OUHSC) campus in Oklahoma City. Oklahoma City offers a dynamic and flourishing downtown area, with low cost of living, short commute times and a diversified economy. The Oklahoman newspaper ranked OMRF as Oklahoma’s #1 large workplace in their annual Best Places to Work survey for 2017 and 2019. OMRF supports a comprehensive postdoctoral training program (


OMRF’s excellence can only be fully realized by individuals who share our commitment to diversity, equity and inclusion. Successful candidates will demonstrate commitment to these values. OMRF is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status or any other legally protected characteristic.


Join our expanding team focused on gene-environmental interactions in the pathogenesis and progression of osteoarthritis. Dr. Matlock Jeffries is seeking a Post-Doctoral Fellow with a strong background in osteoarthritis research to be part of the team working to understand how epigenetic modifications and the microbiome contribute to the development of knee osteoarthritis in human patients and mouse models. The successful candidate will be part of a dynamic lab with synergistic skills and experiences and will be given the opportunity to develop new projects that complement the overall directions of the lab. The team utilizes next-generation sequencing and microarray approaches to DNA methylation analysis, as well as Cas9-based epigenetic editing, RNA-Seq, 16s microbiome, and computational and bioinformatic analyses to expand knowledge of OA pathogenesis. Our laboratory has longstanding experience in the use of DMM surgery to induce OA in mouse models and collaborates with investigators at the leading edge of OA animal model research. Dr. Jeffries’s lab is well funded through multiple NIH and Department of Defense awards. Both Dr. Jeffries and the Arthritis and Clinical Immunology Program of the Oklahoma Medical Research Foundation have a long history of exceptional mentorship.


This is a mentored position for postdoctoral training. Incumbents at this level plan, design and conduct research experiments, manage research projects, prepare reports and papers for publication, presentation and future research, contribute to grant writing and are encouraged to write applications for fellowships. Learn the complexities of research lab management and participate in various lab management responsibilities.


Benchmark Expectations:
- Conduct scientific research.
- Manage research projects.
- Present scientific information both formally and informally, including “big data” sequencing / epigenetic / genetic information.
- Prepare papers for publication.
- Contribute to grant writing.
- Perform lab management responsibilities as assigned.
- Work collaboratively and collegially as part of the team while developing skills needed as an independent scientist.
- Have experience and/or exposure to osteoarthritis or a closely related field.


Knowledge, Skills, and Abilities:
Knowledge of the principles and practices of scientific theory and research; demonstrates skill in formulating and testing hypotheses; ability to conduct scientific research experiments; to analyze and summarize data and results; to write technical, scientific papers; to write grants and to communicate effectively both orally and in writing; to mentor students and guide/direct the work of less senior scientists; to manage a research lab with progressive competency and to demonstrate leadership in a research lab.

Minimum Qualifications

Ph.D. in a biological science, chemistry, physics or other relevant area, or M.D., or equivalent.


OMRF has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment. Applicants must have received, or be willing to receive, a COVID-19 vaccine by their start date to be considered for employment.

Preferred Qualifications

Doctorate in OA research, either basic or translational. History of work in OA mouse models preferred. Publication of at least 2-3 peer-reviewed articles. Experience planning and effectively executing animal projects and maintaining animal colonies. Experience in epigenetics, genetics, or data processing of large genomic datasets preferred but not required. Great communication skills needed. Must have the ability to multitask and work both independently and as a member of an interdisciplinary team with exemplary attention to detail. Must have good computer skills, in the laboratory we routinely use macOS, windows, and linux-based systems. A familiarity with R and/or linux command line is helpful.


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