The Lessard lab is seeking a Post-doctoral Fellow with experience in computational sciences to join our research team. Our research investigates the regulatory functions that control gene expression within the complex landscape of the three-dimensional genome and how genetic variations influence these regulatory functions to cause human diseases such as Sjögren’s syndrome, systemic lupus erythematosus (SLE), and other autoimmune diseases.   We perform a wide variety of high-throughput sequencing technologies in both bulk and single cell technologies: genotyping arrays, RNA-seq, single cell (sc)RNA-seq, Perturb-seq, long sequence Nanopore sequencing, spatial transcriptomics, etc. In addition, we leverage gene-editing technologies, i.e. CRISPR/Cas9 editing, to functionally characterize non-coding regulatory regions of the genome in the context of native 3D chromatin regulatory network using 3C technologies (3C-qPCR, etc.) and promoter capture Micro-C. Candidate must demonstrate proficiency in computer programming (UNIX-like OS, R, and python), and the application of statistical methods commonly used to analyze genetic data. Experience using data analysis pipelines and machine learning analytical approaches is a also preferred.  Candidates must also demonstrate an ability to interpret and summarize research findings, and interest in assisting manuscript preparation and grant writing, and presenting at scientific meetings.

The laboratory of Dr. Pengchun Yu in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists.   We focus on the interface between cellular metabolism and vascular biology and have a proven track record in this field (Circulation Research, 2010; Circulation, 2012; Nature, 2017; J. Biol. Chem., 2021). More information about the lab can be found at https://yulab.omrf.org/. The successful candidates will work on research projects that study the crosstalk between metabolic programs and angiogenic signaling and the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be used, ranging from novel genetically modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.   OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers several critical areas such as cardiovascular disease, autoimmune disease, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories including imaging, next-generation sequencing, and clinical genomics. Moreover, postdoctoral scientists are encouraged to apply for OMRF Postdoc Travel Awards to support their attendance at meetings or workshops.

The Genes and Human Disease Research Program at the Oklahoma Medical Research Foundation (omrf.org) invites candidates to apply for an investigator position at the Assistant Professor level. Current investigators in GHD study questions related to human disease through both model organism and human studies. Our expertise varies from stem cell biology, genome editing, genomics bioinformatics, and neuroepigenetics to human health-related problems including autoimmune diseases, aging, hearing loss, and regeneration. We seek to identify a candidate who will establish an independent research career as well as catalyze collaborative research in our highly interactive program. All investigators at OMRF have access to state-of-the-art core facilities, including an Imaging Core, animal facilities, and modern, next generation sequencing technology and bioinformatics platforms. The successful candidate will receive a generous, multi-year, start-up package with significant salary, equipment, and research funding. OMRF also provides substantial ongoing salary support and research support after the start-up period has ended.

The Yu Lab at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated individual to join our team. We are part of the Cardiovascular Biology Research Program at OMRF. Our research focuses on the interface between cellular metabolism and vascular biology. Specifically, we aim to elucidate the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.   Responsibilities will include:  – Mammalian cell culture and genetic manipulation – Biochemical and cell biology experiments to assess gene expression and function – Mouse tissue dissection, immunohistochemistry, and confocal imaging – Detailed documentation of experiments and results – Participation in lab and department meetings

The Rankin Lab is seeking a Post-doctoral Fellow to study chromosome assembly and dynamics, how these events are controlled, and how corruption of these processes contributes to disease. Our lab forms part of the Program in Cell Cycle and Cancer Biology, which offers an excellent training environment in a state-of-the-art facility. We use a variety of experimental models, including cultured cells, biochemistry, extracts from frog eggs, and advanced microscopy to address problems of chromosome structure, replication, and inheritance. Experience directly related to this field is not necessary, but basic molecular biology skills are preferred. Applicants should demonstrate enthusiasm for the topic, willingness to learn, and the ability to work independently to develop their project(s), analyze experiments, and prepare manuscripts. Successful candidates will have good written and verbal communication skills and be willing to engage fully in lab and departmental activities. During their tenure in the Rankin lab, fellows will receive significant career development support. They can also expect to attend training courses as well as scientific conferences, where they can present their work and establish their presence in the research community.

The Guthridge & James labs (james.omrf.org; Guthridge.omrf.org) are seeking a highly motivated and organized individual to contribute to projects designed to deconstruct the drivers of autoimmune disease at the molecular level in both preclinical and advanced disease states. Studies characterizing the immune cells and their responses against pathogens and autoreactive responses at the cellular and tissue levels using advanced single-cell multiomic phenotyping approaches, high-dimnensional biomarker profiling, and spatial multiomic techniques. Duties will include both basic and advanced cell and molecular biology techniques, such as Luminex and Olink biomarker assays in addition to ELISAs, Western blotting. Single cell techniques including multi-parameter flow cytometry, high-dimensional mass cytometry (CyTOF), imaging mass cytometry (Hyperion), and single cell transcriptomics, proteomics and repertoire using the latest 10X genomics platforms.

The Ahamed lab is looking for a full-time or part-time Research Technician. Our laboratory studies mouse models of heart diseases with a particular focus on fibrosis. We utilize state-of-the-art techniques in genetics, molecular biology, cell biology, and biochemistry. The position involves breeding of our mouse colony, performing experiments utilizing a variety of techniques, analyzing data, contributing to management and contributing to laboratory management and oversight.   Assists, as needed, with administering injections, medications, venipunctures, applying wound dressings, and with diagnostic procedures as directed by supervisor and/or consulting veterinarian.   Identify, prepare and perform a variety of research experiments according to protocol. Projects and assignments are typically non-routine and variable in nature. Receive no instruction on routine work, but receive instructions on new work or special assignments. Collect and present data to Manager or Principal Investigator.

The Oklahoma Medical Research Foundation (OMRF) Multiple Sclerosis Center of Excellence is undergoing an exciting time of clinical and clinical research expansion through generous philanthropic support. We are recruiting two physician investigators with clinical research interests in investigator-initiated clinical trials, outcomes research, or other patient-oriented investigation to join our strong multi-disciplinary MS clinical care and research team. Building on strong clinical research infrastructure with longitudinal cohorts, a cadre of talented clinical coordinators/clinical research nurses, diverse aspects of clinical research informatics and a CAP-certified biorepository, we invite qualified candidates to apply for a clinical investigative position focusing on multiple sclerosis and related disorders. We are currently recruiting at the Assistant/Associate/Full Professor level. Talented candidates at all levels are encouraged to apply and will be considered.   Successful applicants will:   - Spearhead investigator-initiated, sponsor-led and/or NIH clinical trials - Provide comprehensive, optimal, science-driven multiple sclerosis patient care - Receive generous, multi-year start-up package with significant, sustained salary and research support - Collaborate with basic scientists interested in MS patient-oriented translational research - Interact closely with Oklahoma University Health Sciences Center faculty and participate in OUHSC house staff and medical training programs - Contribute toward and enjoy access to: - vibrant patient cohorts with associated patient care and clinical trials infrastructure - extensive autoimmune disease and control bio-specimen collections - outstanding OMRF and ACI Clinical and Research Core facilities   Arthritis and Clinical Immunology investigators have access to a number of outstanding OMRF core facilities, including and state-of-the-art clinical facilities. Extensive autoimmune disease and control sample collections are also available. Pilot programs are also available through the Oklahoma Shared Clinical & Translational Resources funding streams, as well as through the Oklahoma Center for Advancement of Science and Technology. Our clinicians provide outpatient care with no in-patient admission or consulting requirements.   OMRF (http://omrf.org) is an independent, not-for-profit biomedical research institute adjacent to the University of Oklahoma Health Sciences Center (OUHSC) campus in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. For more information about the OMRF MS Center of excellence, please visit: https://omrf.org/patient-studies/multiple-sclerosis/. For more information about the Arthritis and Clinical Immunology Research program, please visit: https://omrf.org/programs/arthritis-clinical-immunology-research-program/.  

Are you passionate about creating a safe and secure environment? Join the Oklahoma Medical Research Foundation (OMRF) and play a crucial role in safeguarding our community. We are seeking a dedicated individual to join our Security Services Department part-time with responsibilities spanning three key categories: Safety & Security • Conduct thorough foot patrols of Foundation buildings and grounds, ensuring the integrity of doors, windows, and gates. • Monitor, operate, and maintain various security systems/equipment, including access control, video surveillance, key tracking, and alert systems. • Swiftly evaluate and address suspicious persons, vehicles, or circumstances, taking appropriate action, including expulsion of violators as needed. • Act as a first responder in security emergencies, coordinating responses to incidents such as fire alarms, bomb threats, medical emergencies, and more. • Stay updated on all security policies and undergo continuous training, including weapon qualification. Customer & Employee Experience • Serve as the first point of contact for visitors, patients, vendors, and employees, leaving a positive impression of the organization. • Build and maintain strong relationships within the organization and collaborate effectively with the University of Oklahoma Health Sciences Center (OUHSC) Police Department. • Monitor and manage the entrance and departure of individuals during regular business hours, special occasions, and events. Administrative • Run reports to analyze card activity, clearances, and other relevant data. • Submit thorough investigatory findings and produce well-documented reports as needed. • Prepare incident, recovered property, and daily log entries, ensuring accurate and comprehensive documentation.

The Ocañas Lab is interested in understanding how biological sex contributes to brain aging and Alzheimer’s disease. We are looking for a highly motivated postdoctoral research fellow to join the multidisciplinary Ocañas Laboratory within the Genes and Human Disease (GHD) Research Program at OMRF. The fellow will investigate how ovarian aging and altered endocrine signaling impacts neuroinflammation in the hippocampus. The successful candidate will employ a wide range of techniques including the generation of novel mouse models, single-cell transcriptomics, epigenomics, flow cytometry, histology & pathological assessments, and a variety of other cellular & molecular biology techniques. The candidate will present their data regularly in laboratory meetings, local seminars and symposiums, and will have opportunities to present their work at national conferences. A requirement of the position is that the candidate must demonstrate ethical behavior at all times, a high-level of scientific rigor, and must be detail-oriented and able to work independently and as part of a team.   The Ocañas Laboratory and GHD Research Program welcome applicants from diverse backgrounds that thrive in a highly collaborative and supportive environment. We are strongly committed to providing individualized mentoring and assistance with career advancement through the implementation of a postdoctoral mentoring committee. The GHD Research Program, which currently consists of 7 highly collaborative investigators, provides an exceptional training environment in genomic techniques and bioinformatics. The OMRF Postdoctoral Association offers additional training opportunities related to grant writing, presentation skills, and career development. The vibrant and highly collaborative environment within OMRF has resulted in the foundation being named the top large employer in the state of Oklahoma three times in the last five years.

The Srinivasan Lab at Oklahoma Medical Research Foundation (OMRF) is recruiting motivated researchers to study lymphatic vascular development and disease and heart valve development and disease. We use biochemical, cell biological and transgenic technologies to dissect the roles of transcription factors and signaling molecules that regulate lymphatic vascular development and disease.   Please check our latest publications: Cha et al (2016) Genes Dev. (cover image) June 16; 30: 1-16; Cha et al (2018) Cell Reports. (cover image) October 16; 25(3):571-584; Mahamud et al (2019) Development. November 5;146(21):dev184218; Geng et al (2020) JCI Insight. (cover image) July 23;5(14):e137652; Chen et al (2020) Development. (cover image) Dec 7;147(23):dev192351; Cha et al (2020) Development. (cover image) Dec 13;147(23):dev195453 and Ho et al (2023)., Circulation research. (cover image and editorial comment), Sep;133(6):463-480.   The ideal candidate will be enthusiastic about challenging projects and will have experience with Molecular Biology, Biochemistry or Immunology. Experience with mouse models is a plus.   Additional information about OMRF can be found at http://omrf.org. Please check the Srinivasan lab website for more information about our research: https://srinivasan.omrf.org/.

The Rice Lab is seeking a Research Technician to conduct research in cellular and molecular mechanisms of Alzheimer’s disease and normal brain function using mouse models. Responsibilities will include, but are not limited to: - Managing mouse colony (updating strain database, setting up breeders, and genotyping by PCR) - Euthanizing mice and dissecting brain tissue - Sectioning, immunostaining, and imaging brain tissue - Participating in lab and departmental meetings

The laboratory of Dr. Brian Coon in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists. The Coon lab studies the physiological relationship between vascular biomechanics and homeostasis, and how the disruption of these circuits contributes to vascular diseases. We are multidisciplinary and welcome applicants with diverse backgrounds. After an initial selection period, applicants will be invited to discuss projects that leverage their scientific interests and technical strengths to address critical questions in vascular biology. Examples of our current projects include the study of - novel mouse genetic models of human diseases, genetic and biochemical drivers of vascular remodeling, crosstalk between mechanotransduction and metabolism pathways, and cell state transitions. OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers critical areas such as cardiovascular disease, autoimmune disease, aging, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories including imaging, next-gen and spatial sequencing, and clinical genomics. Throughout their tenure, postdocs will be offered scientific and career development support through both Dr. Coon and institutional programs. This may include a faculty mentoring committee, grants and manuscript writing, and travel awards to attend international meetings and workshops.

The Zhao Lab is looking for a Research Technician. This position provides an excellent opportunity for an individual who wants to begin a career in science and/or medicine. The Research Technician is expected to perform routine laboratory procedures according to standardized protocols and report results. The individual receives detailed instructions on assignments and regular supervision.   Research projects in the Zhao lab are centered around the regulatory mechanisms for T cell development and functions important for therapeutics against autoimmune diseases, infectious diseases, and cancers. The individual will receive training in state-of-the-art immunology, genetics, molecular biology, and developmental biology techniques. The individual will have opportunities to work with a team on significant projects or lead independent projects.

The Miller Lab is currently hiring for a Research Technician who will design, perform and analyze complex research experiments. Organizes, interprets, and communicates data to supervisor and co-workers. Modifies protocols to improve processes. Documents work appropriately. Troubleshoots problems in lab. May provide guidance to research staff, graduate students, and post docs. Collaborates, builds constructive relationships, and effectively communicates with other members of the lab. Works independently, but seeks assistance when needed. Operates highly specialized equipment requiring moderate to high degree of skill. Expected to perform more advanced techniques after appropriate training. Ability to work well with others is essential.

The Oklahoma Medical Research Foundation (OMRF) Arthritis and Clinical Immunology Department and Rheumatology Center of Excellence is recruiting two physician-investigator faculty members with clinical care and research interests in systemic autoimmune rheumatic diseases. These investigators will be expected to have or to develop vibrant clinical research programs, in areas such as clinical trials, cohort studies, health equity, outcomes research, or other patient-oriented investigation and would join our strong multi-disciplinary Rheumatology clinical care and research teams. Building on strong clinical research infrastructure with longitudinal cohorts, a cadre of talented clinical coordinators/clinical research nurses, diverse aspects of clinical research informatics and a CAP-certified biorepository, we invite qualified candidates to apply for a clinical investigative position focusing on lupus, Sjogren’s, rheumatoid arthritis, and/or UCTD. We are currently recruiting at the Assistant/Associate/Full Professor level and talented candidates at all levels are encouraged to apply.   Successful applicants will: • Provide comprehensive, compassionate, optimal, science-driven Rheumatology patient care • Receive generous, multi-year start-up package with significant, sustained salary and research support • Collaborate with basic scientists interested in Rheumatology patient-oriented translational research • Interact closely with Oklahoma University Health Sciences Center faculty and participate in OUHSC house staff and medical training programs • Contribute toward and enjoy access to:    o vibrant patient cohorts with associated patient care and clinical trials infrastructure    o extensive autoimmune disease and control biospecimen collections    o outstanding OMRF and ACI Clinical and Research Core facilities   Rheumatology investigators also have access to a number of outstanding OMRF core facilities and state-of-the-art clinical facilities. Pilot programs are also available through the Oklahoma Shared Clinical & Translational Resources funding streams, as well as through the Oklahoma Center for Advancement of Science and Technology. Our clinicians provide outpatient care with no in-patient admission or consulting requirements. OMRF (http://omrf.org) is an independent, not-for-profit biomedical research institute adjacent to the University of Oklahoma Health Sciences Center (OUHSC) campus in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. For more information about the OMRF Rheumatology Center of Excellence, please visit: https://omrf.org/patient-studies/rheumatoid-arthritis/. For more information about the Arthritis and Clinical Immunology Research program, please visit: https://omrf.org/programs/arthritis-clinical-immunology-research-program/, https://omrf.org/research-faculty/research-centers/, and https://omrf.org/patient-studies/.

The James/Guthridge labs (james.omrf.org; Guthridge.omrf.org) is a translational immunology laboratory focused on understanding the pathogenesis, prediction, prevention and precision treatment of immune-mediated diseases to improve patients’ lives. We have large, complex experimental datasets partnered with detailed clinical data to help better understand autoimmune disease and improve treatments. Join our dynamic team in a well-funded research group in the Oklahoma Autoimmunity Center of Excellence. We are focused on identifying and characterizing mechanisms of autoimmune disease onset and flare, including regulatory immune mechanisms. Drs. Joel Guthridge (Guthridge.omrf.org) and Judith James (james.omrf.org) are seeking two Post-Doctoral Fellows with a strong immunology background to be part of the team working to understand mechanisms of autoimmune disease in humans by leveraging the extensive resources and data available from our well characterized clinical cohorts. The successful candidate will be part of a dynamic team with synergistic skills and experiences and will be given the opportunity to develop projects that complement the overall directions of the group. The team utilizes high throughput bimolecular assays, deep cellular phenotyping, single cell genomic, proteomic, chromatin conformation/epigenetic and computational and bioinformatics analyses through resources in our departmental Human Phenotyping and Translational Informatics Cores. We also have access to high performance computational resources both in-house and through cloud-based resources. Trainees have the opportunity to participate in large, national NIH-funded consortia. This is a mentored position for postdoctoral training. Individuals at this level plan, design and conduct research experiments; manage research projects; prepare reports and papers for publication, presentation and future research; contribute to grant writing and are encouraged to write applications for fellowships; learn the complexities of research lab management and participate in various lab activities. Benchmark Expectations: - Conduct scientific research - Manage research projects - Present scientific information both formally and informally - Prepare papers for publication - Contribute to grant writing - Perform lab responsibilities as assigned - Work collaboratively and collegially as part of the team while developing skills needed as an independent scientist.   Knowledge, Skills, and Abilities: Knowledge of the principles and practices of scientific theory and research; demonstrates skill in formulating and testing hypotheses; demonstrates ability to conduct scientific research analysis and summarize data and results; writes technical, scientific papers; writes grants and communicates effectively both orally and in writing; mentor students; provides analytic support and input to other projects in the group and guides/directs the work of less senior scientists.

The James/Guthridge labs (james.omrf.org; Guthridge.omrf.org) is a translational immunology laboratory focused on understanding the pathogenesis, prediction, prevention and precision treatment of immune-mediated diseases to improve patients’ lives. We have large, complex experimental datasets partnered with detailed clinical data to help better understand disease and improve treatments. We also help lead large, national, NIH funded consortia such as the Autoimmune Centers of Excellence and Accelerating Medicines Partnership in Autoimmune and Immune-Mediated Disease. We are looking for a talented Scientific/Medical Writer to join our team. The Scientific Writer is responsible for producing and/or editing accurate, clear, and interesting content for manuscripts, grants, reports, lay summaries, white papers, website content and presentations.   The successful candidate will perform some combination of the following. Apply scientific principles and biomedical knowledge to understand, organize, and describe complex data for scientific, medical, and lay audiences. Coordinate input from a multi-disciplinary team while meeting tight deadlines. Help write, edit and proofread key documents. Maintain familiarity with relevant research, conduct literature reviews, and manage references. Assist with the design, development, and selection of scientific illustrations, tables, and figures. Track manuscript status from conceptualization through publication. Assist with cover letters and associated documents. Assist with letters of support, evaluation letters and other aspects of communication like patient newsletters. Update lab and departmental websites, including newsworthy content. Maintain common-use text describing facilities, resources, human subject sections and standard procedures. Assist with editing and writing grant progress reports, grant sections and collaborative grant documents. Summarize research results for lay audiences and community stakeholders. A senior candidate may assume a leadership role for a Scientific Writing Unit, hosting scientific writing workshops, writing groups and lunch-and-learns for junior investigators and trainees.

The James and Guthridge labs are hiring two Assistant/Associate/or full Staff Scientists to design and conduct research experiments; prepare reports presentations and manuscripts for publication; assists with grant writing; and oversee and/or manage research projects, summarize and present results, as well as guiding/leading graduate students, postdocs, and lab staff; may manage staff. Knowledge, Skills, and Abilities: Knowledge of the principles and practices of scientific theory and research; principles of immunology demonstrates skill in formulating and testing hypotheses; ability to conduct scientific research experiments; to analyze and summarize data and results; to write technical, scientific papers; to write grants and to communicate effectively both orally and in writing; to mentor students and guide/direct the work of less senior scientists

The Philanthropy Department is seeking a motivated, positive, self-starter intern to assist with all facets of Philanthropy including, but not limited to: - Note writing, phone calls, new donor research - Assist with outside tours of labs and facilities - Assist with the OMRF Teen Leaders Program - Assist with annual donor events including 241 and the MS Advocate Award Dinner - Other general office administration (filing, scanning, copying, etc.) This position reports directly to the Senior Director of Major Gifts and Outreach.