The Guthridge Lab is seeking a Research Technician for the Biorepository which supports our clinical and translational research investigators. Candidates should be highly organized, motivated and team oriented. Duties will include all repository activities related to receipt, processing, storage, maintenance and records management of human blood and tissue samples related to studies and clinical trials in a CAP (College of American Pathologists) certified facility. Individual will need to be comfortable working in cold temperatures with appropriate personal safety protections and working with human samples.
A postdoctoral research position is available in Dr. Jasim Ahamed’s laboratory to study the role of TGF-beta in organ fibrosis and cardiovascular disease (Antioxid Redox Signal. 2021 (PMID: 34619980); AIDS. 2020 Jun 1;34(7):989-1000 (PMID¨32167970); Blood Adv. 2019 Mar 12;3(5):777-788. (PMID: 30846427); Meyer et al. Blood 2012, 119:1064. (PMID:22134166). We are seeking individuals with experience in biochemistry, molecular biology, in vivo mouse models for cardiovascular disease, and ultrasound imaging techniques.
The Oklahoma Medical Research Foundation (https://omrf.org/) is seeking accomplished or upcoming investigators with expertise in aging as it relates to neuroinflammation and/or neurodegeneration to join the Aging and Metabolism Research Program. Successful candidates will be expected to maintain a vigorous independent research laboratory investigating mechanisms relevant to CNS aging associated with one or more of the following areas of special interest: inflammatory processes, circuits relevant to cognition/behavior, immune cell function, and bioenergetics. Successful candidates will receive an appointment at the Assistant, Associate, or Full Member level (Assistant, Associate, and Full Professor equivalents), dedicated research space, as well as a generous, multi-year start-up package with significant sustained salary and research support.
The Aging and Metabolism Research Program is comprised of thirteen faculty members studying a variety of diseases related to the aging process, including neurological, metabolic, musculoskeletal, and cardiovascular disorders. OMRF supports an AAALAC accredited animal facility as well as state-of-the art core facilities for imaging, -omics technologies, tissue banking, and other facilitating resources. Additional information can be found at the Program’s website (http://omrf.org/programs/aging-and-metabolism-research-program/). Other attractive aspects include a generous startup package, institutional support for competitive salaries, comprehensive benefits, and a collegial work environment. OMRF investigators have no formal teaching obligations but can voluntarily participate in didactic activities on campus at The University of Oklahoma Health Sciences Center (OUHSC). Overall, OMRF is committed to creating an attractive position suitable for applicants with a proven track record or exceptional potential for high-quality funded research.
OMRF is an independent, not-for-profit, biomedical research institute supporting five major interdisciplinary research programs. Our facilities are located adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma City VA Medical Center near downtown Oklahoma City. OMRF investigators are integral participants in OUHSC graduate programs and enjoy close scientific interactions with OUHSC and Oklahoma City VA faculty.
The Rankin Lab is seeking a Post-doctoral Fellow to study chromosome assembly and dynamics, how these events are controlled, and how corruption of these processes contributes to disease. Our lab forms part of the Program in Cell Cycle and Cancer Biology, which offers an excellent training environment in a state-of-the-art facility. We use a variety of experimental models, including cultured cells, biochemistry, extracts from frog eggs, and advanced microscopy to address problems of chromosome structure, replication, and inheritance. Experience directly related to this field is not necessary, but basic molecular biology skills are preferred. Applicants should demonstrate enthusiasm for the topic, willingness to learn, and the ability to work independently to develop their project(s), analyze experiments, and prepare manuscripts. Successful candidates will have good written and verbal communication skills and be willing to engage fully in lab and departmental activities. During their tenure in the Rankin lab, fellows will receive significant career development support. They can also expect to attend training courses as well as scientific conferences, where they can present their work and establish their presence in the research community.
The OMRF Rheumatology Research Center of Excellence is looking for a Phlebotomist/Medical Assistant that will be responsible for the following tasks:
• Responsible for collecting blood, urine, and other samples
• Obtains and understands specimen and test information
• Documents physician orders as required
• Retrieves orders, requisitions, and labels from EMR for accurate collection and labeling of specimens
• Processes samples by centrifugation, pipetting, aliquoting, and slide preparation as required by receiving clinical and research laboratories
• Prepares specimens for transport to lab
• Performs POC testing for CLIA-waived tests
• Maintains accurate records, documents and files as required for both clinical and research databases
• Provides patient results to physician offices, as necessary
• Restocks rooms and supply areas as needed
• Assists with clerical duties such as answering phones, preparing charts, charge entry, assessing and verifying patient test requests and billing information
• Assists nursing staff in obtaining vital signs, weight checks and general patient-comfort needs
• Transports patients and assists staff with moving patients with wheelchairs
• Performs other duties as assigned
- While performing protection duties, Security Officers play an essential public relations role and directly represent OMRF. Act as first contact with visitors, patients, vendors, and/or employees and help ensure a positive impression of the organization. Help form and maintain good relationships between the security department and others in the organization. Positively impact employees’ attitude to report and decrease security risks. Maintain positive, consistent, collaborative relationship with the University of Oklahoma Health Sciences Center (OUHSC) Police Department.
- Monitor entrance and departure of employees, visitors, and other persons during regular business hours and/or special occasions, social events, and conferences to enhance safety program, guard against theft and maintain security of premises. Check visitors in/out.
- Perform foot patrols of Foundation buildings and grounds. Check interior and exterior doors. Ensure doors, windows and gates are secure. Report violations of company security, safety and procedural policies. Report hazardous conditions such as fire risk, water leaks, chemical spills and malfunctioning equipment. Respond to alarms. Raise and lower parking gates. In the event of a power outage, officers may be expected to assist with the manual manipulation of gate(s).
- Monitor, utilize, operate and maintain various security systems/equipment, including but not limited to, access control, video, key tracking, telephone and text alert systems. Run various reports to determine card activity history for a person, door, building and/or elevator; individual’s assigned clearances; and other activity.
- Evaluate, address and take necessary steps with suspicious persons, vehicles or circumstances. Warn violators of rule infractions or violations, such as loitering, illegal parking, or carrying forbidden articles. Apprehend or expel persons engaging in suspicious or criminal acts.
- Provide emergency response. Direct, coordinate, and carry out security responses to fire alarms, bomb threats, suspicious packages, hazardous material releases or spills, medical emergencies, mechanical or equipment failures, extreme weather or other criminal actions. Act as first responder in a security emergency.
- Keep abreast of all security policies and know where they are located for quick reference.
- Perform other duties as assigned by supervisor.
The Yu Lab is currently hiring for a Research Technician to assist with research activities directed toward understanding the roles of cellular metabolism in vascular development and disease. Basic duties will include working with laboratory mice, PCR genotyping, reagent preparation, ordering supplies, and general laboratory maintenance and organization. Additional responsibilities will include molecular and cellular biology and histology.
Job Summary/Basic Function
The Lee laboratory investigates mechanisms of heart diseases using mouse models and molecular techniques. The duties of this position will involve mouse handling (managing mouse colony, ear tagging, injections, blood and tissue sample collection, histology, surgical procedures after proper training), molecular biology techniques (PCR genotyping, quantifications of RNA and protein), reagent preparation, supplies ordering, general laboratory maintenance and organization, and data collection and presentation to the Principal Investigator. Assignments are typically non-routine and variable in nature.
The Clinical Genomics Center (CGC) is seeking highly motivated, detail-oriented individual with molecular laboratory experience to assist in Next Generation Sequencing (NGS) operations. Responsibilites include:
• Work independently within the CGC team to execute projects in a timely manner.
• Perform various molecular biology wet lab tasks (PCR, NGS library prep, sequencing, electrophoresis, PCR purification, DNA quantification, NGS library dilution/normalization and pooling).
• Operate various laboratory equipment (micropipettes, thermocyclers, electrophoresis instruments, liquid-handling robotics, NGS instrumentation)
• Document results in an organized manner.
• Execute protocols with maximum precision and reliability.
• Read and review new protocols and discuss their possible implementation.
• Maintain accurate laboratory logs and records.
• Provide written and verbal updates to supervisor.
• Maintain a safe, clean, and organized work environment.
• Other duties as assigned by supervisor.
The Miller lab is currently hiring for a Research Technician who will design, perform and analyze complex research experiments. Organizes, interprets, and communicates data to supervisor and co-workers. Modifies protocols to improve processes. Documents work appropriately. Troubleshoots problems in lab. May provide guidance to research staff, graduate students, and post docs. Collaborates, builds constructive relationships, and effectively communicates with other members of the lab. Works independently, but seeks assistance when needed. Operates highly specialized equipment requiring moderate to high degree of skill. Expected to perform more advanced techniques after appropriate training. Ability to work well with others is essential.
Verbally greets and registers incoming patients, collects data, enters demographic and insurance information with a high degree of accuracy. Confirms and schedules appointments, collects co-payments, and verifies insurance. Responsibilities iclude:
• Open and close the clinic.
• Answer and correctly route all incoming calls and respond appropriately to inquiries and requests for information.
• Greet patients and other individuals with clinic business. Direct patients and/or visitors to various clinic areas. Assure cleanliness and organization of waiting room.
• Enter patient information on all new patients as well as periodic updating of established patient accounts regarding address, charges incurred, insurance, etc.
• Maintain patient charts and medical records. Ensure completion of and obtain signatures on all necessary forms and documents required by clinic and by law. Photocopy medical records and send out when authorized.
• Consistently obtain and copy/scan insurance cards and drivers licenses.
• Utilize online programs to verify insurance eligibility and benefits, documenting findings on the patient account. Contact insurance companies for pre-authorizations and pre-certifications as required prior to patient receiving services.
• Review insurance verification and advise patient of third party benefits. Explain third party and self-pay portion of bills to patients and/or guarantor.
• Collect copayment. Communicate in a professional manner to patients regarding all outstanding balances. Evaluate financial status of patient’s accounts, initiate and make payment arrangements, and maintain a continuous follow up process on all accounts to minimize loss in revenue.
• Log cash collected, generate receipts, and maintain balanced cash at all times.
• Gather and route billing information appropriately and manage billing work queues and inquiries.
• Maintain clinic schedule including setting patient appointments, confirming appointments with reminder calls, and amending provider schedules according to availability.
• Prepare and send general correspondence and patient letters as directed by providers and/or clinic manager.
• Receive and distribute mail.
• Schedule referrals as directed by the providers to other physicians and/or ancillary services.
• Monitor office supplies in work area to ensure adequate inventory level and advise supervisor of malfunctioning office equipment.
• Perform other related duties as directed that correspond to the overall function of this position.
The Arthritis & Clinical Immunology Research Program is currently hiring for a Project Coordinator/Laboratory Business Administrator.
Oversee the business, purchasing, and accounting for large research groups. Manage various NIH and industry-funded projects by helping set, assess, and measure progress and milestones; monitor progress, track expenses, coordinate multi-investigator activity and ensure compliance with large, complex collaborative NIH grants and investigator-initiated trials; help track and ensure completion, report generation, billing accuracy for various COBRE, ORDRCC, ACE, AMP, NARCH, OSCTR and other multi-investigator and core efforts. Develop, implement and review business plans for ACI scientific and clinical support cores and marketing strategies to improve broad recognition and use of cores and services. Help establish policies and SOPs for select activities and assist with improving efficiencies and streamlining processes. Help with regulatory paperwork for College of American Pathologist certification of the OMRF Biorepository. Interface with OMRF IRB and Technology Ventures to execute MTAs, service agreements and CDAs. Serve as a Marketplace super-user for the labs, negotiating discounts, placing orders, tracking orders/shipments, and keeping an inventory. Provide justifications as requested. Submit invoices to OMRF Accounting for trial expenses. Track preventive maintenances for equipment. Generate quotes for proposed services and submit, track, retain and collect from invoices for core services. Help set and revise fee structures, provide invoicing information and ensure payment for completed activities. Provide at least monthly updates on all account balances and assist with personnel distribution. Review department budgets to identify cost-saving strategies and appropriate spending. Assist with generating budgets and future projections for lab finances. Update content on lab websites. Perform technical and scientific writing for reports and grant applications.
Provide assistance and organization to VP, multiple Principal Investigators (PIs) and staff. Maintain a professional office environment at all times. Manage all calendars, scheduling meetings, sending reminders, and arranging zoom meetings or teleconferencing. Answer multiple phone lines, take messages, and convey them to VP and PIs as necessary. Collect leave requests and timesheets monthly for over 160 employees to check for accuracy, supervisor signatures, etc., for submission to Payroll. Maintain files. Monitor and notify staff, PIs and VP of various deadlines well in advance of due date, especially for membership renewal, abstract, and meeting deadlines. Manage all travel arrangements and reimbursements then coordinate with accounting as needed. Assist organizing PI offices. Assist purchasing office equipment and supplies. Update and organize CVs. Assist with organizing bibliographies and paper collections. Maintain instructions for journal and grant submissions. Assist with letters of support for grants, promotions, applications, etc. Assist with copy editing, graphic preparation, on-line submissions and review that publication or grant submissions meet the requirements of specific journals or granting agencies. Assist with IRB applications and other regulatory documents, as needed. Assist with credentialing for medical organizations, insurance, licensure, and board certification. Organize and maintain records of grant effort distribution. Be able to multi-task and prioritize tasks, while maintaining a positive work orientation.
Provide assistance and organization to multiple Principal Investigators (PIs). Manage grant submissions for NIH and other funding agencies. This includes budget preparation and assembly, copy editing, and review of application for compliance. Correspond with outside institutions and collaborators to gather information for joint applications and subsequent progress reports. Update and organize CVs and Bio sketches for PIs. Assist in organizing bibliographies and published paper collections, monitoring for Public Access compliance. Assist in drafting and/or editing letters, regulatory documents such as IRB or IACUC applications. Maintain strict confidentiality of salary and other sensitive information. Organize and maintain records of grant effort distribution and monthly accounting reports. Monitor and notify PIs of various deadlines for grant reporting and renewal, membership renewal, abstract, and meeting deadlines. Manage PI calendars. Manage travel arrangements and reimbursements. Assist with purchasing office equipment and supplies. Prepare materials for shipment, as needed. Process reimbursements to PIs and lab staff for meetings and other professional expenses. Assist with planning and arranging all aspects of visits for guest speakers, meetings and seminars as required for Department and PIs. Meet with Department Chair weekly, and with PIs as needed to review and coordinate workloads, deadlines, etc., and provide feedback regarding completion of major tasks, office operations and any issues.
The Van Remmen Lab is looking for a Research Technician or Senior Research Technician to conduct basic research in aging, skeletal muscle biology and mitochondrial function through in vitro and in vivo approaches with mice. Specific duties include, but are not limited to mammalian cell culture, western blotting, real time PCR analysis, basic biochemical assays, immunohistochemistry, mouse handling, euthanasia and dissection, and PCR genotyping.
The Bieniasz Lab is looking for a Research Technician that is highly motivated with high focus on professional growth and career advancement. The Research Technician will contribute to projects exploring the mechanisms of ovarian cancer progression, metastasis and chemotherapy resistance. We are investigating various aspects of ovarian cancer development, progression and response to innovative therapies. To study ovarian cancer, we use in vitro mouse and human ovarian cancer cell lines and in vivo mouse models such as genetically engineered mouse models (GEMMs) and patient-derived xenograft (PDX) models of ovarian cancer. The Research Technician will be responsible for performing a wide variety of projects including:
• in vitro cell culture
• mouse colony management
• maintaining cell lines and tumor tissues
• mouse procedures and surgeries
• advanced tumor monitoring and imaging
• preclinical drug efficacy studies
• in vivo data management and analysis
• performing various biochemical and molecular assays
Seeking individuals who will manage and conduct research projects and present scientific/technical information both formally and informally. The Research Technician position is eligible for career advancement if performance goals are met.
Responsible for areas of research administration, including both pre- and post-award functions, and providing sponsored project support from proposal to project close out.
Specific responsibilities include but are not limited to:
- Assisting Principal Investigators/Program Chairs with budgets and other grant application components.
- Reviewing and submitting of grant applications to multiple funding agencies, ensuring compliance with OMRF policies, state and federal regulations, and with the policies, procedures, and requirements of funding agencies.
- Advising and assisting Program Directors/Principal Investigators (PDs/PIs) and department personnel with sponsor awarded projects.
- Responsible for final review of award notices, subcontract agreements and contracts prior to execution and advise supervisor of requirements and provisions that may conflict with OMRF and/or applicable agency policies and practices.
- Monitoring post-award activity applicable to sponsor requirements and restrictions.
- Preparing customized subcontract agreements for institutions that are collaborating on OMRF sponsored grant awards.
- Maintaining relationships with sponsoring agencies and communicating consistently to ensure compliance with sponsor policy.
- Monitoring cost and expenditures on grant accounts to ensure compliance with applicable requirements, regulations and terms and conditions of awards and/or OMB Uniform Guidance.
- Participating in the review and submission of grant reports to the sponsor during the life of the grant award.
- Auditing, evaluating, and preparing reports of expenditures and financial reports on grant and contract transactions.
- Assisting with effort allocations reviews and effort reporting.
- Acting as the liaison between PD/PI and sponsoring agencies to resolve problems, seek approval and answer inquiries regarding the policies of OMRF, the sponsoring agencies, or subcontractors.
- Responsible for accurate, well documented and acceptable set of records and reports on grants and contracts.
- Advising supervisor and/or OMRF leadership of any matters concerning research administration.
- Help train, guide, and advise other grants and contracts team members.
This person is expected to perform routine laboratory procedures according to standardized protocols and report results. She/He receives detailed instructions on assignments and regular supervision. This position provides an excellent opportunity to learn immunology and molecular biology. It also allows the individual to gain experience in general lab management.
Responsibilities to include:
-Making common buffer/solutions and maintaining lab stocks of chemicals
-Basic cell culture procedures
-Basic ELISA procedures
-Basic molecular biology procedures (miniprep/maxiprep/agarose gels)
-Filling/autoclaving tip boxes
-Handling and cataloging clinical samples such as human blood/plasma/serum
-Purification of proteins produced in E. Coli or mammalian cell lines
Performs laboratory procedures according to standardized protocols and reports results. Receives regular supervision for most assignments. Experience with aseptic techniques is preferred and prior experience in basic immunology protocols such as flow cytometry, ELISA, Western blots, and/or immunohistochemistry is highly desired. Individual will need to be comfortable working with human samples and is expected to perform routine work with minimal supervision after appropriate training and time in the position.
Responsibilities will include:
- maintains lab inventory, prepares common lab buffers, and re-order supplies as needed
- maintains donor database and organizes blood collections, either on site or through the Rheumatology Clinic
- processes blood samples and performs basic research protocols (flow cytometry, ELISA, Western blots, etc.)
- prepares written reports and/or presents work at lab meetings
The laboratory of Dr. Meng Zhao in the Arthritis and Clinical Immunology Program at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated postdoctoral fellow/Assistant Staff Scientist to investigate the metabolic regulation of T cells in the pathogenesis of human diseases. The postdoctoral fellow’s project focuses on understanding the mechanistic interaction between metabolic remodeling and immune functions during the development of autoimmune, infectious diseases or cancer. The postdoctoral fellow will work with cutting edge resources including spectral flowcytometry, high resolution microscopy, novel genetically modified mouse models, metabolomic analysis, and single cell transcriptomic analysis.
Founded in 1946, the Oklahoma Medical Research Foundation is one of the nation’s oldest and most respected nonprofit biomedical research institutes. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. Our Arthritis and Clinical Immunology Program is the home base for one of only 10 Autoimmune Centers of Excellence (ACE) in the US. Apart from the close mentorship from Dr. Zhao, the postdoctoral fellow will benefit from departmental journal clubs, seminar series, and the expertise from diverse approaches in the program and the institute. Moreover, OMRF postdoc training committee and postdoc association will provide additional resource and advice. Our collective goal is to help make the postdoc training experience at OMRF productive and successful.
Zhao M*#, Quintana A*, Zhang C*, Andreyev AY*, Kiosses W, Kuwana T, Murphy A, Hogan PG#, Kronenberg M#. Calcium signals regulate the functional differentiation of thymic iNKT cells. EMBO J. 2021 Aug 16;40(16):e107901, PMID: 34169542 (* co-first authors, # co-corresponding authors)
Zhao M*, Svensson M*, Venken K, Sethi A, Engel I, Day JD, Elewaut D, Bottini N, Kronenberg M. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat. Communications. 2018 Jul 6. 9:262 (* co-first author) PMCID: PMC6035278
Chandra S*, Zhao M*, Budelsky A, de Mingo Pulido A, Day J, Fu Z, Siegel L, Smith D, Kronenberg M. A new mouse strain for the analysis of invariant NKT cell function. Nat Immunology. 2015 Aug;16(8):799-800. (* co-first author) PMCID: PMC4711267