The Nath laboratory is seeking a highly motivated, self-starter senior level scientist with the ability to work with optimal resources and little direct supervision to address important questions in the genetics and genomics of systemic lupus erythematosus (SLE or lupus), an autoimmune disease. Using large-scale genome wise association studies (GWAS), our lab has identified several genes/genetic variants associated with lupus susceptibility. Now we are trying to understand the specific functional effects of those lupus associated genetic variants, using cell lines from patient-derived primary immune cells or tissues. We will apply various modern techniques for studying features of three-dimensional (3D) genomic organization such as 3C, Hi-C, ChIP-Seq, RNA-seq and genome editing using CRISPR/Cas9 based techniques. Successful candidate will be proficient in a wide range of analytical methods and the use of bioinformatics/genetics software for analyzing and interpreting various types of data.

The Nath laboratory in the Arthritis and Clinical Immunology research program is seeking a highly motivated, self-starter staff-scientist/post-doctoral level with the ability to work with optimal resources and little direct supervision to address important questions in the genetics and genomics of the systemic lupus erythematosus, an autoimmune diseases. Successful candidates will be proficient in wide range of contemporary molecular biology techniques such as, high-throughput sequencing of DNA, RNA, and methylation, ChIP-Seq, ChIP-qPCR, Single cell genomics, flow cytometry, cloning, cell culture etc. Experience in genome CRISPR/Cas9 or similar approaches will get preference. Competitive individuals will also have some experience in the analysis of genetic data, high-throughput sequencing data and the use of bioinformatics software.

The Nath Lab is seeking a highly motivated, hardworking and organized team player (Post-doctoral Fellow / Assistant Staff Scientist) to join our effort to understand genetic mechanisms of lupus, an autoimmune disease. Using whole genome search, our lab has identified several genes/genetic variants, associated with lupus susceptibility. Now we are trying to understand the specific functional effects of those lupus associated genetic variants, using cell lines, patients-derived primary immune cells or tissues. We will apply various modern techniques for studying features of three-dimensional (3D) genomic organization such as 3C, Hi-C, ChIP-Seq, and genome editing using CRISPR/Cas9. Candidate will be involved in the analysis of human genetic data and the development of computational methods, which requires a mix of computational skills, statistical knowledge, creativity and biological insight. Specifically, candidate will identify novel therapeutic targets and biomarkers from the investigation of human genetic variation (GWAS, Next Gen Sequencing) with disease status and intermediate variables using cutting-edge techniques in Statistical Genetics. Candidate will develop and apply methods for the integration of GWAS summary results with other types of data e.g. eQTL, mQTL, functional genomic annotations, gene networks, estimation/partitioning of heritability, Mendelian Randomization to understand causal direction, and fine mapping. Candidate will collaborate with experimental and clinical scientists to address target mechanism specific questions and seek to support investment decision making with genomic insights.

The Lessard lab is seeking a Post-doctoral Fellow with experience in computational sciences to join our research team. Our research investigates the regulatory functions that control gene expression within the complex landscape of the three-dimensional genome and how genetic variations influence these regulatory functions to cause human diseases such as Sjögren’s syndrome, systemic lupus erythematosus (SLE), and other autoimmune diseases.   We perform a wide variety of high-throughput sequencing technologies in both bulk and single cell technologies: genotyping arrays, RNA-seq, single cell (sc)RNA-seq, Perturb-seq, long sequence Nanopore sequencing, spatial transcriptomics, etc. In addition, we leverage gene-editing technologies, i.e. CRISPR/Cas9 editing, to functionally characterize non-coding regulatory regions of the genome in the context of native 3D chromatin regulatory network using 3C technologies (3C-qPCR, etc.) and promoter capture Micro-C. Candidate must demonstrate proficiency in computer programming (UNIX-like OS, R, and python), and the application of statistical methods commonly used to analyze genetic data. Experience using data analysis pipelines and machine learning analytical approaches is a also preferred.  Candidates must also demonstrate an ability to interpret and summarize research findings, and interest in assisting manuscript preparation and grant writing, and presenting at scientific meetings.

The laboratory of Dr. Pengchun Yu in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists.   We focus on the interface between cellular metabolism and vascular biology and have a proven track record in this field (Circulation Research, 2010; Circulation, 2012; Nature, 2017; J. Biol. Chem., 2021). More information about the lab can be found at https://yulab.omrf.org/. The successful candidates will work on research projects that study the crosstalk between metabolic programs and angiogenic signaling and the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be used, ranging from novel genetically modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.   OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers several critical areas such as cardiovascular disease, autoimmune disease, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories including imaging, next-generation sequencing, and clinical genomics. Moreover, postdoctoral scientists are encouraged to apply for OMRF Postdoc Travel Awards to support their attendance at meetings or workshops.

The Lessard Lab is seeking a highly organized, motivated individual to contribute to projects investigating inflammation and autoimmunity. Duties will include performance of detailed molecular protocols, molecular cloning, quantitative RT-PCR, basic cell culture, ELISA assays, and organization of data into tabular and graphical forms.   

Join our dynamic, well-funded research group in an autoimmune disease center of excellence. We are focused on studying immune mechanisms associated with autoimmunity and translational research questions. Dr. Joel Guthridge and Dr. Judith James are seeking a Post-Doctoral Fellow with a strong immunology and/or bioinformatics/data science background to be part of the team working to apply precision medicine and molecular phenotype classification approaches to clinical and translational autoimmune disease research to improve the lives to patients with autoimmune disease. Large datasets for analysis are already available and growing daily.   The successful candidate will help lead efforts to apply computational and new statistical tools to molecular phenotype pipelines for patient characterization and stratification, assist with data analysis, modeling, visualization and interpretation of clinical and experimental data. We have access to an extensive curated electronic clinical research health record and experimental data warehouse already available to be leveraged for these projects. The team utilizes high throughput bimolecular assays, deep cellular phenotyping, and single cell genomic and proteomic methods through our Human Phenotyping Core. We also have access to high performance computational resources both in-house and through cloud-based resources.   This is a mentored position for postdoctoral training. Incumbents at this level plan, design and conduct analysis plans for research projects; prepare reports and papers for publication, presentation and future research; contribute to grant writing and are encouraged to write applications for fellowships. Successful candidates will learn the complexities of data analytics/research lab management and participate in various lab management responsibilities.   Benchmark Expectations: - Conduct scientific research/data analysis - Manage research projects - Contribute to grant writing; prepare reports and papers for publication - Present scientific/technical information both formally and informally - Work collaboratively and collegially as part of the team while learning to become an independent investigator.   Knowledge, Skills, and Abilities: Knowledge of the principles and practices of scientific theory and research; demonstrates skill in formulating and testing hypotheses; demonstrates ability to conduct scientific research analysis and summarize data and results; writes technical, scientific papers; writes grants and communicates effectively both orally and in writing; mentor students; provides analytic support and input to other projects in the group and guides/directs the work of less senior.

The James/Guthridge labs (james.omrf.org; Guthridge.omrf.org) is a translational immunology laboratory focused on understanding the pathogenesis, prediction, prevention and precision treatment of immune-mediated diseases to improve patients’ lives. We have large, complex experimental datasets partnered with detailed clinical data to help better understand disease and improve treatments. We also help lead large, national, NIH funded consortia such as the Autoimmune Centers of Excellence and Accelerating Medicines Partnership in Autoimmune and Immune-Mediated Disease. We are looking for a talented Scientific/Medical Writer to join our team. The Scientific Writer is responsible for producing and/or editing accurate, clear, and interesting content for manuscripts, grants, reports, lay summaries, white papers, website content and presentations. The successful candidate will perform some combination of the following. Apply scientific principles and biomedical knowledge to understand, organize, and describe complex data for scientific, medical, and lay audiences. Coordinate input from a multi-disciplinary team while meeting tight deadlines. Help write, edit and proofread key documents. Maintain familiarity with relevant research, conduct literature reviews, and manage references. Assist with the design, development, and selection of scientific illustrations, tables, and figures. Track manuscript status from conceptualization through publication. Assist with cover letters and associated documents. Assist with letters of support, evaluation letters and other aspects of communication like patient newsletters. Update lab and departmental websites, including newsworthy content. Maintain common-use text describing facilities, resources, human subject sections and standard procedures. Assist with editing and writing grant progress reports, grant sections and collaborative grant documents. Summarize research results for lay audiences and community stakeholders. A senior candidate may assume a leadership role for a Scientific Writing Unit, hosting scientific writing workshops, writing groups and lunch-and-learns for junior investigators and trainees.

The Yoon Lab is looking for a highly motivated, organized, responsible person who will play a key role in achieving the mission of the lab. Using Drosophila (fruit fly), we aim to discover cellular and molecular mechanisms how metabolic dysfunctions cause human diseases including neurological diseases. We utilize variety of approaches including genetics, metabolomics, biochemistry, cell and molecular biology as well as confocal and electron microscopy.   Responsibilities will include: - Maintenance of Drosophila stocks - Conducting genetic experiments to assess gene function in Drosophila - Prep of Drosophila tissue samples and imaging using fluorescent and confocal microscopes - Conducting basic molecular biology experiments such as PCR and cloning - Detailed documentation of experiments and results - Participation in lab and departmental meetings

The Genes and Human Disease Research Program at the Oklahoma Medical Research Foundation (omrf.org) invites candidates to apply for an investigator position at the Assistant Professor level. Current investigators in GHD study questions related to human disease through both model organism and human studies. Our expertise varies from stem cell biology, genome editing, genomics bioinformatics, and neuroepigenetics to human health-related problems including autoimmune diseases, aging, hearing loss, and regeneration. We seek to identify a candidate who will establish an independent research career as well as catalyze collaborative research in our highly interactive program. All investigators at OMRF have access to state-of-the-art core facilities, including an Imaging Core, animal facilities, and modern, next generation sequencing technology and bioinformatics platforms. The successful candidate will receive a generous, multi-year, start-up package with significant salary, equipment, and research funding. OMRF also provides substantial ongoing salary support and research support after the start-up period has ended. OMRF is an independent, not-for-profit biomedical research institute adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. Oklahoma City offers a dynamic and burgeoning midtown area near the campus, and a very reasonable cost of living.   We are committed to addressing additional needs of faculty, including dual career couples and single parents. We are particularly focused on overcoming barriers to gender equity in science. OMRF is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status, or any other legally protected characteristic.

The Van Remmen Lab is looking for a Research Technician or Senior Research Technician to conduct basic research in aging, skeletal muscle biology and mitochondrial function through in vitro and in vivo approaches with mice. Specific duties include, but are not limited to mammalian cell culture, western blotting, real time PCR analysis, basic biochemical assays, immunohistochemistry, mouse handling, euthanasia and dissection, and PCR genotyping.

The Lee Lab investigates mechanisms of heart diseases using mouse models and molecular techniques.   The duties of this position will involve mouse handling (managing mouse colony, ear tagging, injections, blood and tissue sample collection, histology, surgical procedures after proper training), molecular biology techniques (PCR genotyping, quantifications of RNA and protein), reagent preparation, supplies ordering, general laboratory maintenance and organization, and data collection and presentation to the Principal Investigator. Assignments are typically non-routine and variable in nature.

The Yu Lab at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated individual to join our team. We are part of the Cardiovascular Biology Research Program at OMRF. Our research focuses on the interface between cellular metabolism and vascular biology. Specifically, we aim to elucidate the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.   Responsibilities will include:  – Mammalian cell culture and genetic manipulation – Biochemical and cell biology experiments to assess gene expression and function – Mouse tissue dissection, immunohistochemistry, and confocal imaging – Detailed documentation of experiments and results – Participation in lab and department meetings

The Rankin Lab is seeking a Post-doctoral Fellow to study chromosome assembly and dynamics, how these events are controlled, and how corruption of these processes contributes to disease. Our lab forms part of the Program in Cell Cycle and Cancer Biology, which offers an excellent training environment in a state-of-the-art facility. We use a variety of experimental models, including cultured cells, biochemistry, extracts from frog eggs, and advanced microscopy to address problems of chromosome structure, replication, and inheritance. Experience directly related to this field is not necessary, but basic molecular biology skills are preferred. Applicants should demonstrate enthusiasm for the topic, willingness to learn, and the ability to work independently to develop their project(s), analyze experiments, and prepare manuscripts. Successful candidates will have good written and verbal communication skills and be willing to engage fully in lab and departmental activities. During their tenure in the Rankin lab, fellows will receive significant career development support. They can also expect to attend training courses as well as scientific conferences, where they can present their work and establish their presence in the research community.

The Oklahoma Medical Research Foundation (https://omrf.org/) is seeking accomplished or upcoming investigators with expertise in aging as it relates to neuroinflammation and/or neurodegeneration to join the Aging and Metabolism Research Program. Successful candidates will be expected to maintain a vigorous independent research laboratory investigating mechanisms relevant to CNS aging associated with one or more of the following areas of special interest: inflammatory processes, circuits relevant to cognition/behavior, immune cell function, and bioenergetics. Successful candidates will receive an appointment at the Assistant, Associate, or Full Member level (Assistant, Associate, and Full Professor equivalents), dedicated research space, as well as a generous, multi-year start-up package with significant sustained salary and research support. The Aging and Metabolism Research Program is comprised of thirteen faculty members studying a variety of diseases related to the aging process, including neurological, metabolic, musculoskeletal, and cardiovascular disorders.  OMRF supports an AAALAC accredited animal facility as well as state-of-the art core facilities for imaging, -omics technologies, tissue banking, and other facilitating resources. Additional information can be found at the Program’s website (http://omrf.org/programs/aging-and-metabolism-research-program/). Other attractive aspects include a generous startup package, institutional support for competitive salaries, comprehensive benefits, and a collegial work environment. OMRF investigators have no formal teaching obligations but can voluntarily participate in didactic activities on campus at The University of Oklahoma Health Sciences Center (OUHSC). Overall, OMRF is committed to creating an attractive position suitable for applicants with a proven track record or exceptional potential for high-quality funded research. OMRF is an independent, not-for-profit, biomedical research institute supporting five major interdisciplinary research programs. Our facilities are located adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma City VA Medical Center near downtown Oklahoma City.  OMRF investigators are integral participants in OUHSC graduate programs and enjoy close scientific interactions with OUHSC and Oklahoma City VA faculty.   EOE/AA Employer/Vet/Disabled

The Lee laboratory at the Cardiovascular Biology Research Program (CVB) of OMRF is seeking Postdoctoral Fellows to lead research projects. Our NIH-funded research program (https://leelab.omrf.org/) investigates mechanisms linking mitochondrial and NAD+ metabolism to pathogenesis of cardiometabolic diseases. Fellows will have access to resources and equipment for cardiac physiology and electrophysiology, metabolism, cardiomyocyte and mitochondrial function, proteomics, metabolomics, informatics and spatial transcriptomics from the Lee lab, CVB, CMRO-CoBRE (https://cellularmetabolism-cobre.omrf.org/), OMRF core facilities (https://omrf.org/research-faculty/core-facilities/) and collaborations.   Candidates must be self-motivated, proactive and enthusiastic about their research career development. The Principal Investigator (PI) and the postdoctoral mentoring committee will be committed to prepare fellows for an independent research career. Candidates are expected to work independently and contribute intellectually to facilitate a stimulating environment within the research group and among research programs at OMRF. OMRF’s postdoctoral fellow association (https://omrf.org/about-omrf/education-outreach/postdoctoral-programs/postdoc-association/) seeks to enhance the training experience by providing scientific, social interaction opportunities and funds to support attendance at scientific meetings or workshops.   Successful candidates will have a recent doctoral degree (within 0-3 years or expect to receive the degree within a year) in cardiovascular physiology, biochemistry or related biomedical disciplines. First-authored publication(s) from the graduate work is expected. Prior research experience and publication(s) investigating cardiometabolic diseases in mouse model are required. Experience in echocardiography, electrophysiology and surgical techniques for heart disease is a plus.

The Guthridge & James labs (james.omrf.org; Guthridge.omrf.org) are seeking a highly motivated and organized individual to contribute to projects designed to deconstruct the drivers of autoimmune disease at the molecular level in both preclinical and advanced disease states. Studies characterizing the immune cells and their responses against pathogens and autoreactive responses at the cellular and tissue levels using advanced single-cell multiomic phenotyping approaches, high-dimnensional biomarker profiling, and spatial multiomic techniques. Duties will include both basic and advanced cell and molecular biology techniques, such as Luminex and Olink biomarker assays in addition to ELISAs, Western blotting. Single cell techniques including multi-parameter flow cytometry, high-dimensional mass cytometry (CyTOF), imaging mass cytometry (Hyperion), and single cell transcriptomics, proteomics and repertoire using the latest 10X genomics platforms.

The Ahamed lab is looking for a full-time or part-time Research Technician. Our laboratory studies mouse models of heart diseases with a particular focus on fibrosis. We utilize state-of-the-art techniques in genetics, molecular biology, cell biology, and biochemistry. The position involves breeding of our mouse colony, performing experiments utilizing a variety of techniques, analyzing data, contributing to management and contributing to laboratory management and oversight.   Assists, as needed, with administering injections, medications, venipunctures, applying wound dressings, and with diagnostic procedures as directed by supervisor and/or consulting veterinarian.   Identify, prepare and perform a variety of research experiments according to protocol. Projects and assignments are typically non-routine and variable in nature. Receive no instruction on routine work, but receive instructions on new work or special assignments. Collect and present data to Manager or Principal Investigator.

The Oklahoma Medical Research Foundation (OMRF) Multiple Sclerosis Center of Excellence is undergoing an exciting time of clinical and clinical research expansion through generous philanthropic support. We are recruiting two physician investigators with clinical research interests in investigator-initiated clinical trials, outcomes research, or other patient-oriented investigation to join our strong multi-disciplinary MS clinical care and research team. Building on strong clinical research infrastructure with longitudinal cohorts, a cadre of talented clinical coordinators/clinical research nurses, diverse aspects of clinical research informatics and a CAP-certified biorepository, we invite qualified candidates to apply for a clinical investigative position focusing on multiple sclerosis and related disorders. We are currently recruiting at the Assistant/Associate/Full Professor level. Talented candidates at all levels are encouraged to apply and will be considered.   Successful applicants will:   - Spearhead investigator-initiated, sponsor-led and/or NIH clinical trials - Provide comprehensive, optimal, science-driven multiple sclerosis patient care - Receive generous, multi-year start-up package with significant, sustained salary and research support - Collaborate with basic scientists interested in MS patient-oriented translational research - Interact closely with Oklahoma University Health Sciences Center faculty and participate in OUHSC house staff and medical training programs - Contribute toward and enjoy access to: - vibrant patient cohorts with associated patient care and clinical trials infrastructure - extensive autoimmune disease and control bio-specimen collections - outstanding OMRF and ACI Clinical and Research Core facilities   Arthritis and Clinical Immunology investigators have access to a number of outstanding OMRF core facilities, including and state-of-the-art clinical facilities. Extensive autoimmune disease and control sample collections are also available. Pilot programs are also available through the Oklahoma Shared Clinical & Translational Resources funding streams, as well as through the Oklahoma Center for Advancement of Science and Technology. Our clinicians provide outpatient care with no in-patient admission or consulting requirements.   OMRF (http://omrf.org) is an independent, not-for-profit biomedical research institute adjacent to the University of Oklahoma Health Sciences Center (OUHSC) campus in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. For more information about the OMRF MS Center of excellence, please visit: https://omrf.org/patient-studies/multiple-sclerosis/. For more information about the Arthritis and Clinical Immunology Research program, please visit: https://omrf.org/programs/arthritis-clinical-immunology-research-program/.  

The Ocañas Lab is hiring a Research Technician to contribute to projects focused on brain aging and neurodegeneration using in vivo mouse models.   Primary responsibilities will include mouse colony management (breeding, genotyping, record keeping), molecular biology techniques (qPCR, sequencing library preparation), and regular lab maintenance tasks. Other skills will be added as needed to support the research program. In-depth training will be provided for all tasks (no advanced experience required).