The Bodine Lab is seeking a research technician to conduct research in cellular and molecular mechanisms regulating skeletal muscle size and function in response to disease and aging using rodent models. Responsibilities will include, but are not limited to: - Managing mouse colony (updating strain database, setting up breeders, and genotyping by PCR) - Exercise training of laboratory animals - Euthanizing animals and dissecting muscle tissue - Sectioning, immunostaining, and imaging muscle tissue - Participating in lab and departmental meetings

The Mao-Draayer Lab is looking for a highly motivated, organized, responsible person who will play a key role in achieving the mission of the lab. We aim to discover cellular and molecular mechanisms how immune dysfunctions cause human autoimmune diseases including multiple sclerosis, neuromyelitis optica, and other neuroinflammatory disease. We utilize variety of approaches including immunology, genetics, metabolomics, biochemistry, cell and molecular biology. Responsibilities will include: - Collecting human blood sample and PBMC isolations - Conducting flowcytometry immunophenotyping experiments as well as to assess immune cell functions - Conducting basic molecular biology experiments such as PCR, Western, tissue culture - Detailed documentation of experiments and results - Summarizing lab results and presenting at meetings - Participating in lab and departmental meetings

The Guthridge Lab is seeking a Research Technician for the Biorepository which supports our clinical and translational research investigators. Candidates should be highly organized, motivated and team oriented. Duties will include all repository activities related to receipt, processing, storage, maintenance and records management of human blood and tissue samples related to studies and clinical trials in a CAP (College of American Pathologists) certified facility. Individual will need to be comfortable working in cold temperatures with appropriate personal safety protections and working with human samples.

• Reviews requisitions, verifying accuracy, terminology, specifications. Approves requisitions for conversion to Purchase Orders. • Confers with vendors to obtain product or service information such as price, availability, and delivery schedule. • Estimates values according to knowledge of market price. • Prepares bid requests when required. • Reviews bid proposals and negotiates contracts within budgetary limitations and to scope of authority. • Maintains procurement records (e.g.: items or services purchased, costs, delivery, product quality or performance, and inventories) • Troubleshoots with users, vendors, and others regarding defective or unacceptable goods or services and determines source of trouble and takes corrective action. • Assists and coordinates with the Accounting Department the processing of completed purchase order payments. • Approves invoices for payment. • Expedites delivery of goods/services to users. • Processes and ships returned goods to vendor and ensures proper credits are received. • Consults catalogs and interviews suppliers to obtain prices and specifications. • Prepares purchase orders and sends copies to supplier when a hard copy is required. • Compares prices, specifications, and delivery dates to provide best value for end users. • Verifies invoices from suppliers with bids/quotes and purchase orders and approves payment. • Performs other duties as assigned by the supervisor.

The Scofield Lab is looking for a Summer Research Intern. This internship in the Arthritis & Clinical Immunology department will provide motivated students the opportunity to assist with research studies directed towards understanding the mechanisms of osteoarthritis. Duties may include performing a variety of cell culture and molecular biology techniques, extraction, analysis, and presentation of data.

The Freeman Lab is currently hiring for a Research Technician who will design, perform, and analyze neuroscience experiments. Job responsibilities will include organizing, interpreting, and communicating data to supervisor and co-workers. Responsibilities will also include improve experimental processes, documenting work appropriately and troubleshooting experiments. The position will collaborate and effectively communicate with other members of the lab. The position will work independently at times and also seek assistance from more experienced team members when needed. These studies include operating highly specialized equipment and performing advanced techniques after appropriate training. Ability to work well with others is essential.

The Deshmukh Labat the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated individual to join our team. We are part of the Arthritis and Clinical Immunology Research Program at OMRF. The primary focus of our laboratory is to investigate how aging influences autoimmunity and salivary gland disease. Our lab employs animal model systems to gain in-depth knowledge of disease mechanisms. We feel this is key for developing novel diagnostic and therapeutic strategies to treat autoimmune and autoinflammatory disorders. Over the past 10 years, many research technicians from my laboratory have joined graduate schools in the US, including OUHSC. Individuals with keen interest in progressing their careers in research are highly encouraged to apply.   Responsibilities will include: – Mammalian cell culture – Biochemical and cell biology experiments to assess gene expression and function – Mouse tissue dissection, immunohistochemistry, and confocal imaging – Provide assistance in Flow Cytometry experiments – Detailed documentation of experiments and results – Participation in lab and department meetings

The OMRF Clinical Immunology Laboratory is seeking a conscientious, highly motivated, organized individual to perform high complexity testing to detect myositis-specific or myositis-associated autoantibodies in patient samples. This laboratory serves as a tertiary referral center for complex autoantibody testing to aid in the diagnosis and prognosis of autoimmune rheumatic disease patients, primarily inflammatory myositis. Duties include tissue culture, western blotting, immunoprecipitation, electrophoresis, autoradiography, result interpretation, and standard lab functions. This position will focus particular attention on RNA immunoprecipitation. Data will need to be entered into a standard database. Candidates need to be able to work independently with minimal supervision, but also have a team orientation. Candidates must be able to adhere to the College of American Pathologist (CAP) guidelines and University Radioactivity guidelines.

1. Performs cleaning, sanitization, and preparation of caging and accessories by processing dirty and clean cages and equipment for a variety of laboratory animal species in a timely manner. 2. Operates equipment including autoclaves, mechanical washers, bedding dispenser, per department SOP's. 3. Perform daily maintenance requirements of equipment as per SOP's and notify supervisor of any equipment malfunctions. 4. Sanitize all areas of facility per department SOP's. 5. Maintain quality control records. 6. Observe SOP's for traffic flow within facility to prevent cross-contamination. 7. Assist with monitoring facility environment, notify supervisor of any problems detected. 8. Receive and store incoming supplies; maintain storage room. 9. Performs all other duties as assigned.     General Responsibilities 1. Performs, as directed, safety compliance and uses Personal Protective Equipment (PPE), as needed. 2. Participates in Quality Assessment (QA) and Quality Improvement (QI) programs, as directed. 3. Maintains positive working relationships as a team player through problem solving issues, speaking positively about others, listening attentively and observing the confidentiality of research needs. 4. Increases customer service knowledge, skill and ability by participating in departmental training program. 5. Delivers service that exceeds expectations by problem solving with other employees as appropriate 6. Maintains a clean and safe working environment.

The laboratory of Dr. Meng Zhao in the Arthritis and Clinical Immunology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated postdoctoral fellow/Assistant Staff Scientist to investigate the metabolic regulation of T cells in the pathogenesis of human diseases. The fellow’s project focuses on understanding the mechanistic interaction between metabolic remodeling and immune functions during the development of autoimmune, infectious diseases or cancer. The postdoctoral fellow will work with cutting edge resources including spectral flowcytometry, high resolution microscopy, novel genetically modified mouse models, metabolomic analysis, and single cell transcriptomic analysis.   OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. Arthritis and Clinical Immunology Program is the home base for one of only 10 Autoimmune Centers of Excellence (ACE) in the US. Apart from the close mentorship from Dr. Zhao, the fellow will benefit from departmental journal clubs, seminar series, and the expertise from diverse approaches in the program and the institute. Moreover, OMRF postdoc training committee and postdoc association will provide additional resource and advice. Our collective goal is to help make the training experience at OMRF productive and successful.   Selected publications Zhao M*#, Quintana A*, Zhang C*, Andreyev AY*, Kiosses W, Kuwana T, Murphy A, Hogan PG#, Kronenberg M#. Calcium signals regulate the functional differentiation of thymic iNKT cells. EMBO J. 2021 Aug 16;40(16):e107901, PMID: 34169542 (* co-first authors, # co-corresponding authors)   Zhao M*, Svensson M*, Venken K, Sethi A, Engel I, Day JD, Elewaut D, Bottini N, Kronenberg M. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat. Communications. 2018 Jul 6. 9:262 (* co-first author) PMCID: PMC6035278   Chandra S*, Zhao M*, Budelsky A, de Mingo Pulido A, Day J, Fu Z, Siegel L, Smith D, Kronenberg M. A new mouse strain for the analysis of invariant NKT cell function. Nat Immunology. 2015 Aug;16(8):799-800. (* co-first author) PMCID: PMC4711267