The Oklahoma Medical Research Foundation (https://omrf.org/) is seeking accomplished or upcoming investigators with expertise in aging as it relates to neuroinflammation and/or neurodegeneration to join the Aging and Metabolism Research Program. Successful candidates will be expected to maintain a vigorous independent research laboratory investigating mechanisms relevant to CNS aging associated with one or more of the following areas of special interest: inflammatory processes, circuits relevant to cognition/behavior, immune cell function, and bioenergetics. Successful candidates will receive an appointment at the Assistant, Associate, or Full Member level (Assistant, Associate, and Full Professor equivalents), dedicated research space, as well as a generous, multi-year start-up package with significant sustained salary and research support.   The Aging and Metabolism Research Program is comprised of thirteen faculty members studying a variety of diseases related to the aging process, including neurological, metabolic, musculoskeletal, and cardiovascular disorders.  OMRF supports an AAALAC accredited animal facility as well as state-of-the art core facilities for imaging, -omics technologies, tissue banking, and other facilitating resources. Additional information can be found at the Program’s website (http://omrf.org/programs/aging-and-metabolism-research-program/). Other attractive aspects include a generous startup package, institutional support for competitive salaries, comprehensive benefits, and a collegial work environment. OMRF investigators have no formal teaching obligations but can voluntarily participate in didactic activities on campus at The University of Oklahoma Health Sciences Center (OUHSC). Overall, OMRF is committed to creating an attractive position suitable for applicants with a proven track record or exceptional potential for high-quality funded research. OMRF is an independent, not-for-profit, biomedical research institute supporting five major interdisciplinary research programs. Our facilities are located adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma City VA Medical Center near downtown Oklahoma City.  OMRF investigators are integral participants in OUHSC graduate programs and enjoy close scientific interactions with OUHSC and Oklahoma City VA faculty.     EOE/AA Employer/Vet/Disabled

The Rankin Lab is seeking a Post-doctoral Fellow to study chromosome assembly and dynamics, how these events are controlled, and how corruption of these processes contributes to disease. Our lab forms part of the Program in Cell Cycle and Cancer Biology, which offers an excellent training environment in a state-of-the-art facility. We use a variety of experimental models, including cultured cells, biochemistry, extracts from frog eggs, and advanced microscopy to address problems of chromosome structure, replication, and inheritance. Experience directly related to this field is not necessary, but basic molecular biology skills are preferred. Applicants should demonstrate enthusiasm for the topic, willingness to learn, and the ability to work independently to develop their project(s), analyze experiments, and prepare manuscripts. Successful candidates will have good written and verbal communication skills and be willing to engage fully in lab and departmental activities. During their tenure in the Rankin lab, fellows will receive significant career development support. They can also expect to attend training courses as well as scientific conferences, where they can present their work and establish their presence in the research community.

The Yu Lab is currently hiring for a Research Technician to assist with research activities directed toward understanding the roles of cellular metabolism in vascular development and disease. Basic duties will include working with laboratory mice, PCR genotyping, reagent preparation, ordering supplies, and general laboratory maintenance and organization. Additional responsibilities will include molecular and cellular biology and histology.

Job Summary/Basic Function The Lee laboratory investigates mechanisms of heart diseases using mouse models and molecular techniques. The duties of this position will involve mouse handling (managing mouse colony, ear tagging, injections, blood and tissue sample collection, histology, surgical procedures after proper training), molecular biology techniques (PCR genotyping, quantifications of RNA and protein), reagent preparation, supplies ordering, general laboratory maintenance and organization, and data collection and presentation to the Principal Investigator. Assignments are typically non-routine and variable in nature.

The Arthritis & Clinical Immunology Research Program is currently hiring for a Project Coordinator/Laboratory Business Administrator.   Oversee the business, purchasing, and accounting for large research groups. Manage various NIH and industry-funded projects by helping set, assess, and measure progress and milestones; monitor progress, track expenses, coordinate multi-investigator activity and ensure compliance with large, complex collaborative NIH grants and investigator-initiated trials; help track and ensure completion, report generation, billing accuracy for various COBRE, ORDRCC, ACE, AMP, NARCH, OSCTR and other multi-investigator and core efforts. Develop, implement and review business plans for ACI scientific and clinical support cores and marketing strategies to improve broad recognition and use of cores and services. Help establish policies and SOPs for select activities and assist with improving efficiencies and streamlining processes. Help with regulatory paperwork for College of American Pathologist certification of the OMRF Biorepository. Interface with OMRF IRB and Technology Ventures to execute MTAs, service agreements and CDAs. Serve as a Marketplace super-user for the labs, negotiating discounts, placing orders, tracking orders/shipments, and keeping an inventory. Provide justifications as requested. Submit invoices to OMRF Accounting for trial expenses. Track preventive maintenances for equipment. Generate quotes for proposed services and submit, track, retain and collect from invoices for core services. Help set and revise fee structures, provide invoicing information and ensure payment for completed activities. Provide at least monthly updates on all account balances and assist with personnel distribution. Review department budgets to identify cost-saving strategies and appropriate spending. Assist with generating budgets and future projections for lab finances. Update content on lab websites. Perform technical and scientific writing for reports and grant applications.

Provide assistance and organization to VP, multiple Principal Investigators (PIs) and staff. Maintain a professional office environment at all times. Manage all calendars, scheduling meetings, sending reminders, and arranging zoom meetings or teleconferencing. Answer multiple phone lines, take messages, and convey them to VP and PIs as necessary. Collect leave requests and timesheets monthly for over 160 employees to check for accuracy, supervisor signatures, etc., for submission to Payroll. Maintain files. Monitor and notify staff, PIs and VP of various deadlines well in advance of due date, especially for membership renewal, abstract, and meeting deadlines. Manage all travel arrangements and reimbursements then coordinate with accounting as needed. Assist organizing PI offices. Assist purchasing office equipment and supplies. Update and organize CVs. Assist with organizing bibliographies and paper collections. Maintain instructions for journal and grant submissions. Assist with letters of support for grants, promotions, applications, etc. Assist with copy editing, graphic preparation, on-line submissions and review that publication or grant submissions meet the requirements of specific journals or granting agencies. Assist with IRB applications and other regulatory documents, as needed. Assist with credentialing for medical organizations, insurance, licensure, and board certification. Organize and maintain records of grant effort distribution. Be able to multi-task and prioritize tasks, while maintaining a positive work orientation.

The Van Remmen Lab is looking for a Research Technician or Senior Research Technician to conduct basic research in aging, skeletal muscle biology and mitochondrial function through in vitro and in vivo approaches with mice. Specific duties include, but are not limited to mammalian cell culture, western blotting, real time PCR analysis, basic biochemical assays, immunohistochemistry, mouse handling, euthanasia and dissection, and PCR genotyping.

The Finn Lab at OMRF is looking for an innovative, dedicated scientist for a full-time staff scientist position. We study how variability in genome organization can give rise to cellular phenotypes. You will be trained in techniques specific to the lab. You will bring your own expertise. Together, we’ll develop an exciting, independent research project that you will oversee and manage. As the work develops, there will be opportunities for mentorship of students, publication, and formal and informal presentations.   Benchmark Accountabilities: • Independently conducts scientific research • Oversees and/or manages a research project • Mentors more junior lab members • Shares in regular lab maintenance tasks • Assists with grant writing and writing papers for publication • Presents scientific information both formally and informally   Knowledge, Skills, and Abilities: • Knowledge of the principles and practices of scientific theory and research • Skill in formulating and testing hypotheses • Verbal and written communication skills • Ability to design and conduct scientific research experiments • Ability to analyze and summarize data and results • Ability to write scientific papers and grants • Ability to mentor students and guide the work of less senior scientists

The Finn Lab at OMRF is looking for excellent candidates for a position at the level of postdoctoral research fellow. We study how variability in genome organization can give rise to cellular phenotypes. You will be trained in techniques specific to the lab. You will bring your own expertise. Together, we’ll develop an exciting, independent research project that you will oversee and manage. As the work develops, there will be opportunities for grant-writing, mentorship of students, publication, and formal and informal presentations. The eventual goal is to help you build the independence you need to advance your career.   Benchmark Accountabilities: • Independently conducts scientific research • Oversees and/or manages a research project • Mentors more junior lab members • Shares in regular lab maintenance tasks • Assists with grant writing and writing papers for publication • Apply for training grants and other funding if eligible with assistance and guidance • Presents scientific information both formally and informally   Knowledge, Skills, and Abilities: • Knowledge of the principles and practices of scientific theory and research • Skill in formulating and testing hypotheses • Verbal and written communication skills • Ability to design and conduct scientific research experiments • Ability to analyze and summarize data and results • Ability to write scientific papers and grants • Ability to mentor students and guide the work of less senior scientists

Coordinates and executes rheumatology research projects. Performs nursing duties in a rheumatology research clinic setting including research and data management, patient care, sample collection and processing, and medication administration. Tasks require a high level of organizational skills and the ability to ask the right questions to determine proper course of action while following established standards and research protocols.   DUTIES: 1. Clinical Trials. Conducts research and assists researchers by recruiting patients, determining eligibility for clinical trials, and seeing patients through research studies including obtaining informed consent, administering questionnaires, taking medical histories, study drug administration, assessing and reporting adverse events, and performing all study related tasks as outlined in study protocols and in adherence with GCP, ICH, and HIPAA regulations. 2. Chart Review. Performs medical chart review to abstract data for research including but not limited to constructing medical history and medications chronology, evaluating disease progression, and mapping symptom and biomarker associations. 3. Communication. Liaises between principal investigator, patients, third party patient care service providers, research sponsors, and governing agencies to ensure strict adherence to protocol and regulations throughout study conduct. Excellent written and oral communications required. 4. Patient Care. Assesses and records symptoms, vital signs, and other patient information required for research protocols and to prepare patient for examination. Review records for documentation of study inclusion/exclusion criteria. Carries out physician orders for testing and treatment and coordinates follow-up care of patients. 5. Sample Collection. Collects samples from patients including blood, urine, saliva, etc. Prepares samples for analysis or shipment. Collects all laboratory reports, data, and records. Excellent phlebotomy skills required. 6. Medication Administration. Under direction of physician or other medical personnel, administers FDA approved and investigational medications to patients. IV certification preferred. 7. Data Management. Gathers, organizes, analyzes, and submits patient and research data to principal investigators, scientists, and sponsors. Computer skills required. 8. As Needed. Performs various duties as needed to successfully fulfill the function of the position.

The Genes and Human Disease Research Program at the Oklahoma Medical Research Foundation (omrf.org) invites candidates to apply for an investigator position at the Assistant Member level (Assistant Professor equivalent). Current investigators in GHD study questions related to human disease through both model organism and human studies. Our expertise varies from stem cell biology, genome editing, genomics bioinformatics, and neuroepigenetics to human health-related problems including autoimmune diseases, aging, hearing loss, and regeneration. We seek to identify a candidate who will establish an independent research career as well as catalyze collaborative research in our highly interactive program. All investigators at OMRF have access to state-of-the-art core facilities, including an Imaging Core, animal facilities, and modern, next generation sequencing technology and bioinformatics platforms. The successful candidate will receive a generous, multi-year, start-up package with significant salary, equipment, and research funding. OMRF also provides substantial ongoing salary support and research support after the start-up period has ended. OMRF is an independent, not-for-profit biomedical research institute adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. Oklahoma City offers a dynamic and burgeoning midtown area near the campus, and a very reasonable cost of living.   We are committed to addressing additional needs of faculty, including dual career couples and single parents. We are particularly focused on overcoming barriers to gender equity in science. OMRF is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status, or any other legally protected characteristic.

The James lab is looking for a Program Manager to assist with the leadership and program management of national, high-visibility NIH & Industry funded project portfolio focused on clinical-and translational research programs across multiple autoimmune diseases including lupus, rheumatoid arthritis, Sjogren’s syndrome and psoriatic spectrum diseases. The successful applicant will be an organized, high-energy project manager at the center of the administrative management of multiple NIH and industry funded projects to include the following responsibilities: 1) draft and implement program policies and procedures 2) help set, assess and report on program progress and milestones 3) coordinate overall program budget allocations between subproject sites and funding organizations 4) coordinate and document proceedings of the program steering committee, leadership and subproject committee meetings 5) ensure all parties of programs are in compliance with all regulatory obligations including material transfer agreements, human subjects research training, and institutional review board protocol approvals 5) assist with the logistics and compliance of clinical operations and sample processing training 6) monitor deadlines and deliverables helping to re-aliquot resources and ensure all parties are meeting and exceeding expectations, 7) assembling slide presentations to highlight progress and emphasize areas needing additional help, 8) helping monitor and document publications, presentations and summary documents. In addition, this position will also engage in management of other divisional activities for multiple investigators, collaborative NIH grants, and investigator-initiated clinical trials. Such management activities include but are not limited to establishing policies and SOPs for select divisional areas and assist with improving efficiencies and streamlining processes, verification of billing and expenses across lab/divisional multi-investigator projects, technical and scientific writing for reports and grant applications, marketing of clinical resources and technology core capabilities to attract investments by BioPharma in Arthritis & Clinical Immunology opportunities.

Provide assistance and organization to multiple Principle Investigators (PIs) in the Arthritis and Clinical Immunology Research Program. Update and organize CVs and Biosketches for PIs. Assist in organizing bibliographies and published paper collections, monitoring for Public Access compliance. Assist in drafting and/or editing letters, regulatory documents such as IRB or IACUC applications. Organize and maintain records of grant effort distribution and monthly accounting reports. Monitor and notify PIs of various deadlines well in advance of due date for grant reporting and renewal, membership renewal, abstract, and meeting deadlines. Manage PI calendars. Gather timesheets and get PI signatures. Manage travel arrangements and reimbursements. Assist with purchasing office equipment and supplies. Assist with planning and arranging all aspects of visits for guest speakers, meetings, seminars, and symposia as required for department and PIs. Meet with PIs as needed to review and coordinate workloads, deadlines, etc., and provide feedback regarding completion of major tasks, office operations and any issues. Requesting or pulling publications. Must have a helpful orientation and positive attitude. Filing, copying, picking up/delivering mail, and other administrative tasks. Opportunities to learn grant and manuscript preparation and submission skills.

The Yoon Lab is looking for a highly motivated, organized, responsible person who will play a key role in achieving the mission of the lab. Using Drosophila (fruit fly), we aim to discover cellular and molecular mechanisms how metabolic dysfunctions cause human diseases including neurological diseases. We utilize variety of approaches including genetics, metabolomics, biochemistry, cell and molecular biology as well as confocal and electron microscopy.   Responsibilities will include: - Maintenance of Drosophila stocks - Conducting genetic experiments to assess gene function in Drosophila - Prep of Drosophila tissue samples and imaging using fluorescent and confocal microscopes - Conducting basic molecular biology experiments such as PCR and cloning - Detailed documentation of experiments and results - Participation in lab and departmental meetings

The Kinter laboratory in the Aging and Metabolism Research Program is seeking a Research Technician. The Kinter laboratory has two parts; a proteomics laboratory that helps other scientists use LC-MS in their experiments and an independent research program studying the effects of high fat diets on the heart.   The Research Technician will perform routine laboratory procedures according to our laboratory protocols, including but not limited to handling mice, maintaining cell cultures, isolating protein and RNA, gel electrophoresis, Western blotting, and LC-mass spectrometry. They will receive general instructions on routine work and detailed instructions on new assignments.

 The Yoon Lab is looking for a highly motivated, creative, and responsible scientists who will play a key role in achieving the mission of the lab. We aim to discover cellular and molecular mechanisms of Mendelian mitochondrial diseases. To do this, we implement an experimental pipeline that leverages the combined power of clinical data, genomics analysis, and studies using Drosophila models and patient-derived stem cell models. We have discovered 5 new Mendelian mitochondrial diseases including the Harel-Yoon syndrome that bears my name. We have established disease models in Drosophila and human iPS cells. Hence, the motivated postdoctoral researchers are expected to discover new findings and publish high-impact papers.   Researchers with strong interest in neurological and mitochondrial diseases are welcome to apply. Expertise in any of the following areas is highly valued though not required: - Drosophila genetics - Metabolism/mitochondrial biology - Neurodegeneration & Neurodevelopmental diseases - Developmental biology - iPSCs/cerebral organoids

The James/Guthridge labs (james.omrf.org; Guthridge.omrf.org) is a translational immunology laboratory focused on understanding the pathogenesis, prediction, prevention and precision treatment of immune-mediated diseases to improve patients’ lives. We have large, complex experimental datasets partnered with detailed clinical data to help better understand disease and improve treatments. We also help lead large, national, NIH funded consortia such as the Autoimmune Centers of Excellence and Accelerating Medicines Partnership in Autoimmune and Immune-Mediated Disease. We are looking for a talented Scientific/Medical Writer to join our team. The Scientific Writer is responsible for producing and/or editing accurate, clear, and interesting content for manuscripts, grants, reports, lay summaries, white papers, website content and presentations. The successful candidate will perform some combination of the following. Apply scientific principles and biomedical knowledge to understand, organize, and describe complex data for scientific, medical, and lay audiences. Coordinate input from a multi-disciplinary team while meeting tight deadlines. Help write, edit and proofread key documents. Maintain familiarity with relevant research, conduct literature reviews, and manage references. Assist with the design, development, and selection of scientific illustrations, tables, and figures. Track manuscript status from conceptualization through publication. Assist with cover letters and associated documents. Assist with letters of support, evaluation letters and other aspects of communication like patient newsletters. Update lab and departmental websites, including newsworthy content. Maintain common-use text describing facilities, resources, human subject sections and standard procedures. Assist with editing and writing grant progress reports, grant sections and collaborative grant documents. Summarize research results for lay audiences and community stakeholders. A senior candidate may assume a leadership role for a Scientific Writing Unit, hosting scientific writing workshops, writing groups and lunch-and-learns for junior investigators and trainees.

The James/Guthridge labs (james.omrf.org; Guthridge.omrf.org) is a translational immunology laboratory focused on understanding the pathogenesis, prediction, prevention and precision treatment of immune-mediated diseases to improve patients’ lives. We have large, complex experimental datasets partnered with detailed clinical data to help better understand disease and improve treatments.   Join our dynamic team in a well-funded research group in an autoimmune disease center of excellence. We are focused on identifying and characterizing mechanisms of autoimmune disease onset and flare, including regulatory immune mechanisms. Drs. Joel Guthridge (Guthridge.omrf.org) and Judith James (james.omrf.org) are seeking two Post-Doctoral Fellows with a strong immunology background to be part of the team working to understand mechanisms of autoimmune disease in humans by leveraging the extensive resources and data available from our well characterized clinical cohorts. The successful candidate will be part of a dynamic team with synergistic skills and experiences and will be given the opportunity to develop projects that complement the overall directions of the group. The team utilizes high throughput bimolecular assays, deep cellular phenotyping, single cell genomic, proteomic, chromatin conformation/epigenetic and computational and bioinformatics analyses through resources in our Human Phenotyping and Translational Informatics Cores which are supported through NIH P30 U54 and U19 mechanisms. We also have access to high performance computational resources both in-house and through cloud-based resources. Trainees have the opportunity to participate in large, national NIH-funded consortia.   This is a mentored position for postdoctoral training. Individuals at this level plan, design and conduct research experiments; manage research projects; prepare reports and papers for publication, presentation and future research; contribute to grant writing and are encouraged to write applications for fellowships; learn the complexities of research lab management and participate in various lab activities.   Benchmark Expectations: - Conduct scientific research - Manage research projects - Present scientific information both formally and informally - Prepare papers for publication - Contribute to grant writing - Perform lab responsibilities as assigned - Work collaboratively and collegially as part of the team while developing skills needed as an independent scientist. Knowledge, Skills, and Abilities: Knowledge of the principles and practices of scientific theory and research; demonstrates skill in formulating and testing hypotheses; demonstrates ability to conduct scientific research analysis and summarize data and results; writes technical, scientific papers; writes grants and communicates effectively both orally and in writing; mentor students; provides analytic support and input to other projects in the group and guides/directs the work of less senior scientists.

Join our dynamic, well-funded research group in an autoimmune disease center of excellence. We are focused on studying immune mechanisms associated with autoimmunity and translational research questions. Dr. Joel Guthridge and Dr. Judith James are seeking a Post-Doctoral Fellow with a strong immunology and/or bioinformatics/data science background to be part of the team working to apply precision medicine and molecular phenotype classification approaches to clinical and translational autoimmune disease research to improve the lives to patients with autoimmune disease. Large datasets for analysis are already available and growing daily.   The successful candidate will help lead efforts to apply computational and new statistical tools to molecular phenotype pipelines for patient characterization and stratification, assist with data analysis, modeling, visualization and interpretation of clinical and experimental data. We have access to an extensive curated electronic clinical research health record and experimental data warehouse already available to be leveraged for these projects. The team utilizes high throughput bimolecular assays, deep cellular phenotyping, and single cell genomic and proteomic methods through our Human Phenotyping Core. We also have access to high performance computational resources both in-house and through cloud-based resources.   This is a mentored position for postdoctoral training. Incumbents at this level plan, design and conduct analysis plans for research projects; prepare reports and papers for publication, presentation and future research; contribute to grant writing and are encouraged to write applications for fellowships. Successful candidates will learn the complexities of data analytics/research lab management and participate in various lab management responsibilities.   Benchmark Expectations: - Conduct scientific research/data analysis - Manage research projects - Contribute to grant writing; prepare reports and papers for publication - Present scientific/technical information both formally and informally - Work collaboratively and collegially as part of the team while learning to become an independent investigator.   Knowledge, Skills, and Abilities: Knowledge of the principles and practices of scientific theory and research; demonstrates skill in formulating and testing hypotheses; demonstrates ability to conduct scientific research analysis and summarize data and results; writes technical, scientific papers; writes grants and communicates effectively both orally and in writing; mentor students; provides analytic support and input to other projects in the group and guides/directs the work of less senior.

The James/Guthridge labs (james.omrf.org; Guthridge.omrf.org) is a translational immunology laboratory focused on understanding the pathogenesis, prediction, prevention and precision treatment of immune-mediated diseases to improve patients’ lives. We have large, complex experimental datasets partnered with detailed clinical data to help better understand disease and improve treatments. We are looking for a Biostatistician or experienced Data Analyst to join our team to help analyze current and emerging data. This person will perform biostatistic analyses of clinical trial and associated experimental data. Develops data analysis plans, including power calculations. Performs a wide variety of analyses, including but not limited to parametric and non-parametric statistics. Evaluates the statistical methods and procedures used to obtain data and to ensure validity, applicability, efficiency, accuracy, reliability and usability of data. Reports results of statistical analyses, including information in the form of graphs, charts, and tables. Conveys results for presentations to non-statistical audiences. Analyzes and interprets statistical data and prepares conclusions. Identifies relationships and trends in data, as well as any factors that could affect the results of research. Assists scientists in designing experiments to facilitate correct analysis of data. Plans data collection methods for specific projects and determines the types and sizes of sample groups to be used. Queries databases and manages datasets.